Abstract
Controllable exploding polyelectrolyte microcapsules were developed by layer-by-layer assembly of poly(allylamine hydrochloride) (PAH) and poly(sodium 4-styrenesulfonate) (PSS) on a dextran microgel core containing a cleavable disulfide bond fabricated via click chemistry. The microcapsules can explode upon the injection of DTT with an explosive release of the drug.
© The Royal Society of Chemistry 2011
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Capsules
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Click Chemistry
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Dextrans / chemistry
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Dithiothreitol / chemistry
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Drug Carriers / chemistry*
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Hydrogen-Ion Concentration
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Models, Molecular
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Molecular Conformation
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Polyamines / chemistry
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Polymers / chemistry
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Sulfonic Acids / chemistry
Substances
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Capsules
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Dextrans
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Drug Carriers
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Polyamines
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Polymers
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Sulfonic Acids
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polyallylamine
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Dithiothreitol
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styrenesulfonic acid polymer