Controllable exploding microcapsules as drug carriers

Chem Commun (Camb). 2011 Apr 21;47(15):4457-9. doi: 10.1039/c1cc10337g. Epub 2011 Mar 9.

Abstract

Controllable exploding polyelectrolyte microcapsules were developed by layer-by-layer assembly of poly(allylamine hydrochloride) (PAH) and poly(sodium 4-styrenesulfonate) (PSS) on a dextran microgel core containing a cleavable disulfide bond fabricated via click chemistry. The microcapsules can explode upon the injection of DTT with an explosive release of the drug.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Capsules
  • Click Chemistry
  • Dextrans / chemistry
  • Dithiothreitol / chemistry
  • Drug Carriers / chemistry*
  • Hydrogen-Ion Concentration
  • Models, Molecular
  • Molecular Conformation
  • Polyamines / chemistry
  • Polymers / chemistry
  • Sulfonic Acids / chemistry

Substances

  • Capsules
  • Dextrans
  • Drug Carriers
  • Polyamines
  • Polymers
  • Sulfonic Acids
  • polyallylamine
  • Dithiothreitol
  • styrenesulfonic acid polymer