Novel mutations in a patient isolate of Streptococcus agalactiae with reduced penicillin susceptibility emerging after long-term oral suppressive therapy

Antimicrob Agents Chemother. 2011 Jun;55(6):2983-5. doi: 10.1128/AAC.01243-10. Epub 2011 Mar 7.

Abstract

Penicillin nonsusceptibility has been demonstrated in group B streptococci (GBS), but there is limited information regarding mechanisms of resistance. We report a case of GBS with reduced susceptibility to penicillin emerging after long-term suppressive oral penicillin therapy for a prosthetic joint infection. Molecular characterization of the isolate before and after long-term penicillin therapy revealed 5 mutations in the ligand-binding regions of PBP1a, -2a, and -2x not previously reported in GBS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Aged
  • Computer Simulation
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Mutation*
  • Penicillin Resistance*
  • Penicillin-Binding Proteins / genetics*
  • Penicillins / administration & dosage
  • Penicillins / pharmacology*
  • Streptococcus agalactiae / drug effects*
  • Streptococcus agalactiae / genetics*

Substances

  • Penicillin-Binding Proteins
  • Penicillins