Cytotoxic clerodane diterpenes from Casearia rupestris

Gerardo M Vieira-Júnior; Luiz A Dutra; Paulo M P Ferreira; Manoel O de Moraes; Letícia V Costa Lotufo; Cláudia do Ó Pessoa; Roseli Buzanelli Torres; Nivaldo Boralle; Vanderlan da S Bolzani; Alberto J Cavalheiro

doi:10.1021/np100840w

Cytotoxic clerodane diterpenes from Casearia rupestris

J Nat Prod. 2011 Apr 25;74(4):776-81. doi: 10.1021/np100840w. Epub 2011 Mar 7.

Authors

Gerardo M Vieira-Júnior¹, Luiz A Dutra, Paulo M P Ferreira, Manoel O de Moraes, Letícia V Costa Lotufo, Cláudia do Ó Pessoa, Roseli Buzanelli Torres, Nivaldo Boralle, Vanderlan da S Bolzani, Alberto J Cavalheiro

Affiliation

¹ Institute of Chemistry, Nucley of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, C.P. 14801-970, Araraquara, SP, Brazil.

PMID: 21381705
DOI: 10.1021/np100840w

Abstract

Four new clerodane diterpenes, casearupestrins A-D (1-4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6). All compounds were evaluated for cytotoxicity against a small panel of human cancer cell lines. Casearupestrin A (1) exhibited the most potent activity against MDA/MB-435 (human melanoma) and SF-295 (human glioblastoma) cells, superior to that of the standard drug doxorubicin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology*
Brazil
Casearia / chemistry*
Diterpenes, Clerodane / chemistry
Diterpenes, Clerodane / isolation & purification*
Diterpenes, Clerodane / pharmacology*
Doxorubicin / pharmacology
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Plant Leaves / chemistry

Substances

Antineoplastic Agents, Phytogenic
Diterpenes, Clerodane
Doxorubicin