Abstract
Whole cells of Rhodotorula glutinis reduced N-methyl-3-oxo-3-(thiophen-2-yl) propanamide at 30 g/l to (S)-N-methyl-3-hydroxy-3-(2-thienyl) propionamide, an intermediate in the production of (S)-duloxetine, a blockbuster antidepressant drug, in 48 h. The reaction had excellent enantioselectivity (single enantiomer, >99.5% enantiomeric excess [ee]) with a >95% conversion.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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DNA, Fungal / chemistry
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DNA, Fungal / genetics
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DNA, Ribosomal / chemistry
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DNA, Ribosomal / genetics
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Duloxetine Hydrochloride
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Genes, rRNA
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Molecular Sequence Data
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Oxidation-Reduction
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RNA, Fungal / genetics
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RNA, Ribosomal, 18S / genetics
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Rhodotorula / enzymology*
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Rhodotorula / genetics
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Rhodotorula / isolation & purification
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Rhodotorula / metabolism*
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Sequence Analysis, DNA
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Stereoisomerism
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Thiophenes / metabolism*
Substances
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DNA, Fungal
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DNA, Ribosomal
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RNA, Fungal
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RNA, Ribosomal, 18S
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Thiophenes
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Duloxetine Hydrochloride