Engineering Nanocarriers for siRNA Delivery

Shawn J Tan; Pichamon Kiatwuthinon; Young Hoon Roh; Jason S Kahn; Dan Luo

doi:10.1002/smll.201001389

Engineering Nanocarriers for siRNA Delivery

Small. 2011 Apr 4;7(7):841-56. doi: 10.1002/smll.201001389. Epub 2011 Feb 25.

Authors

Shawn J Tan¹, Pichamon Kiatwuthinon, Young Hoon Roh, Jason S Kahn, Dan Luo

Affiliation

¹ Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USA.

PMID: 21374801
DOI: 10.1002/smll.201001389

Abstract

The discovery of RNA interference has revitalized the long ongoing pursuit of gene therapy for the treatment of diseases. Nevertheless, despite promising results from experimental studies, there remains a pressing need for the development of nanocarriers that are clinically-relevant, biocompatible, efficient, and that can be tailored to specific disease targets. This review surveys the broad spectrum of nanomaterials and their functional add-ons, and aims to provide a guide towards engineering nanocarriers for effective siRNA delivery.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Genetic Therapy / methods
Nanoparticles / administration & dosage
Nanoparticles / chemistry*
Neoplasms / therapy
RNA Interference
RNA, Small Interfering / administration & dosage*
RNA, Small Interfering / therapeutic use

Substances

RNA, Small Interfering