Abstract
Leiodermatolide is a structurally unique macrolide, isolated from the deep-water marine sponge Leiodermatium sp., which exhibits potent antiproliferative activity against a range of human cancer cell lines (IC50 <10 nM) and dramatic effects on spindle formation in mitotic cells. Its unprecedented polyketide skeleton and stereochemistry were established using a combination of experimental and computational (DP4) NMR methods, and molecular modelling.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimitotic Agents / chemistry*
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Antimitotic Agents / pharmacology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Macrolides / chemistry*
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Macrolides / pharmacology
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Mitosis / drug effects
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Oceans and Seas
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Porifera / chemistry*
Substances
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Antimitotic Agents
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Macrolides
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leiodermatolide