Ceramicines E-I, new limonoids from Chisocheton ceramicus

Chem Pharm Bull (Tokyo). 2011;59(3):407-11. doi: 10.1248/cpb.59.407.

Abstract

Five new limonoids, ceramicines E-I (1-5), have been isolated from the bark of Chisocheton ceramicus. The structures and relative stereochemistry of them were fully elucidated based on 1D- and 2D-NMR data. Ceramicines E-I (1-5) exhibited moderate cell growth inhibitory activities on a range of cell lines (HL-60, A549, MCF7, and HCT116). The absolute structure of previously isolated ceramicine B (6) was also elucidated by circular dichroism (CD) and X-ray analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Circular Dichroism
  • Crystallography, X-Ray
  • Humans
  • Limonins / chemistry*
  • Limonins / isolation & purification
  • Limonins / toxicity
  • Magnetic Resonance Spectroscopy
  • Meliaceae / chemistry*
  • Molecular Conformation
  • Plant Bark / chemistry

Substances

  • Limonins