Abstract
The leaves of the endemic Philippine plant, Dillenia philippinensis yielded 11 compounds including one new sulfated glucoside and a new seco-A-ring oleanane-type triterpenoid. The molecular structures of these compounds were elucidated by means of NMR, MS and other spectroscopic techniques, as well as by comparison with literature data. Anti-Leishmania activity and cytotoxic activity against A549 human lung adenocarcinoma cells were also examined.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiparasitic Agents / chemistry*
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Antiparasitic Agents / isolation & purification
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Antiparasitic Agents / pharmacology
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Cell Line, Tumor
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Dilleniaceae / chemistry*
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Glucosides / chemistry*
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Glucosides / isolation & purification
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Glucosides / pharmacology
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Humans
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Conformation
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Oleanolic Acid / analogs & derivatives*
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Oleanolic Acid / chemistry
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Oleanolic Acid / isolation & purification
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Oleanolic Acid / pharmacology
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Philippines
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Plant Leaves / chemistry
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Sulfates / chemistry
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Triterpenes / chemistry*
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Triterpenes / isolation & purification
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Triterpenes / pharmacology
Substances
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2,3-seco-olean-12-ene-2,3,28-trioic acid
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Antiparasitic Agents
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Glucosides
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Sulfates
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Triterpenes
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Oleanolic Acid