Chemical studies on an endemic Philippine plant: sulfated glucoside and seco-A-ring triterpenoids from Dillenia philippinensis

Chem Pharm Bull (Tokyo). 2011;59(3):397-401. doi: 10.1248/cpb.59.397.

Abstract

The leaves of the endemic Philippine plant, Dillenia philippinensis yielded 11 compounds including one new sulfated glucoside and a new seco-A-ring oleanane-type triterpenoid. The molecular structures of these compounds were elucidated by means of NMR, MS and other spectroscopic techniques, as well as by comparison with literature data. Anti-Leishmania activity and cytotoxic activity against A549 human lung adenocarcinoma cells were also examined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiparasitic Agents / chemistry*
  • Antiparasitic Agents / isolation & purification
  • Antiparasitic Agents / pharmacology
  • Cell Line, Tumor
  • Dilleniaceae / chemistry*
  • Glucosides / chemistry*
  • Glucosides / isolation & purification
  • Glucosides / pharmacology
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Conformation
  • Oleanolic Acid / analogs & derivatives*
  • Oleanolic Acid / chemistry
  • Oleanolic Acid / isolation & purification
  • Oleanolic Acid / pharmacology
  • Philippines
  • Plant Leaves / chemistry
  • Sulfates / chemistry
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology

Substances

  • 2,3-seco-olean-12-ene-2,3,28-trioic acid
  • Antiparasitic Agents
  • Glucosides
  • Sulfates
  • Triterpenes
  • Oleanolic Acid