Abstract
Five new eunicellin-type diterpenoids, cladieunicellins A-E (1-5), were isolated from an Indonesian soft coral identified as Cladiella sp. The structures of diterpenoids 1-5 were established using spectroscopic methods. Eunicellins 2 and 5 were found to be cytotoxic against DLD-1 and HL-60 tumor cells, respectively, and 3 displayed inhibitory effects against superoxide anion generation by human neutrophils.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / toxicity
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / toxicity
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Drug Screening Assays, Antitumor
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Humans
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Indonesia
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Neutrophils / drug effects
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Superoxides / metabolism
Substances
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Antineoplastic Agents
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Diterpenes
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Superoxides