Cladieunicellins A-E, new eunicellins from an Indonesian soft coral Cladiella sp

Chem Pharm Bull (Tokyo). 2011;59(3):353-8. doi: 10.1248/cpb.59.353.

Abstract

Five new eunicellin-type diterpenoids, cladieunicellins A-E (1-5), were isolated from an Indonesian soft coral identified as Cladiella sp. The structures of diterpenoids 1-5 were established using spectroscopic methods. Eunicellins 2 and 5 were found to be cytotoxic against DLD-1 and HL-60 tumor cells, respectively, and 3 displayed inhibitory effects against superoxide anion generation by human neutrophils.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / toxicity
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Diterpenes / toxicity
  • Drug Screening Assays, Antitumor
  • Humans
  • Indonesia
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Neutrophils / drug effects
  • Superoxides / metabolism

Substances

  • Antineoplastic Agents
  • Diterpenes
  • Superoxides