InACTIVatINg cancer cachexia

Dis Model Mech. 2011 May;4(3):283-5. doi: 10.1242/dmm.007658. Epub 2011 Mar 3.

Abstract

Summary of and comment on a recent Cell paper entitled ‘Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival’ (Zhou et al., 2010).

MeSH terms

  • Activin Receptors, Type II / metabolism
  • Activins / metabolism*
  • Animals
  • Cachexia / complications*
  • Cachexia / metabolism*
  • Disease Models, Animal
  • Humans
  • Mice
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / pathology
  • Neoplasms / complications*
  • Neoplasms / metabolism*
  • Signal Transduction
  • Transforming Growth Factor beta / metabolism

Substances

  • Transforming Growth Factor beta
  • Activins
  • Activin Receptors, Type II
  • activin receptor type II-B