Mycobacterium tuberculosis in a HIV-1-infected population from Southeastern Brazil in the HAART era

Trop Med Int Health. 2011 Jan;16(1):67-73. doi: 10.1111/j.1365-3156.2010.02681.x.

Abstract

Objective: To evaluate retrospectively the microbiological profile of Mycobacterium species isolated from HIV-infected patients attending the HIV/TB reference health care units in São José do Rio Preto, Brazil.

Method: Retrospective evaluation of all HIV-1 positive patients whose IAL-SJRP laboratorial analysis was positive for Mycobacterium sp. after diagnosis of HIV Infection, from January 2000 to December 2006.

Results: Of 198 patients, acid-fast staining detected mycobacteria early in 41%. Culture revealed 52.5% to be infected with Mycobacterium tuberculosis (MT). 42.4% had non-tuberculous mycobacteria (NTM) and 5.1% had MT/NTM positive cultures. Eleven per cent of MT strains were resistant to at least one of the antimycobacterial drugs and 3.1% were multidrug resistant. 39.4% of isolated mycobacteria were NTM species.

Conclusion: Our data may serve as a starting point for further comparisons with other Brazilian regions and other developing countries. The data may provide important clues to the future understanding, prevention and control of such co-infections around the world.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS-Related Opportunistic Infections / complications*
  • AIDS-Related Opportunistic Infections / microbiology
  • Adult
  • Aged
  • Antiretroviral Therapy, Highly Active
  • Drug Resistance, Bacterial
  • Female
  • HIV-1*
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Mycobacterium / classification
  • Mycobacterium / drug effects
  • Mycobacterium / isolation & purification*
  • Mycobacterium Infections / complications*
  • Mycobacterium Infections / microbiology
  • Retrospective Studies
  • Tuberculosis / complications
  • Young Adult