Abstract
One-pot synthesis of symmetric 1,4-disubstituted 1,3-diynes from iodoarenes and propiolic acid via Sonogashira reaction followed by Pd-catalyzed decarboxylative homocoupling is developed in high yields. Also, this system allows the one-pot synthesis of unsymmetric 1,4-disubstituted 1,3-diynes by cross-coupling of two different 3-substituted propiolic acids.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes / chemistry*
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Catalysis
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Combinatorial Chemistry Techniques
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Cross-Linking Reagents / chemistry
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Diynes / chemical synthesis*
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Diynes / chemistry*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Palladium / chemistry*
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Propionates / chemistry*
Substances
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Alkynes
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Cross-Linking Reagents
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Diynes
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Propionates
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Palladium
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propiolic acid