Abstract
Various skin hyperpigmentation disorders consist in accumulation and overproduction of melanin. In this report, we investigated the melanogenesis inhibitory and antioxidant effects of Bifidobacterium bifidum culture filtrate. The results revealed that B. bifidum culture filtrate effectively suppresses murine tyrosinase activity and decreases the amount of intracellular melanin in a dose-dependent manner. Additionally, the bacterial culture filtrate-scavenged DPPH and ABTS radicals, and shows potent-reducing power in a dose-dependent pattern. Our results expand the application of B. bifidum culture filtrate in the development and research of skin-whitening ingredients.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Agaricales
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Animals
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Antioxidants / pharmacology
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Benzothiazoles / metabolism
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Bifidobacterium / growth & development
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Bifidobacterium / metabolism*
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Biphenyl Compounds / metabolism
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Cells, Cultured
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Chick Embryo
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Culture Media, Conditioned / pharmacology*
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Enzyme Activation / drug effects
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Fungal Proteins / antagonists & inhibitors*
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Hyperpigmentation / drug therapy*
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Hyperpigmentation / metabolism
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Hyperpigmentation / microbiology
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Melanins / metabolism*
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Mice
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Monophenol Monooxygenase / antagonists & inhibitors*
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Picrates / metabolism
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Sulfonic Acids / metabolism
Substances
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Antioxidants
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Benzothiazoles
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Biphenyl Compounds
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Culture Media, Conditioned
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Fungal Proteins
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Melanins
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Picrates
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Sulfonic Acids
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2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
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1,1-diphenyl-2-picrylhydrazyl
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Monophenol Monooxygenase