Two new α-pinene derivatives from Angelica sinensis and their anticoagulative activities

Fitoterapia. 2011 Jun;82(4):692-5. doi: 10.1016/j.fitote.2011.02.007. Epub 2011 Feb 25.

Abstract

Two new α-pinene derivatives (1-2) were isolated from the aerial parts of Angelica sinensis. Their structures were determined by spectroscopic and chemical methods to be 6β,9-dihydroxy-(+)-α-pinene (1) and 9-hydroxy-(+)-α-pinene-6β-O-D-glucoside (2). In the anticoagulative assay, compounds 1 and 2 exhibited weak antithrombin activity and strong antiplatelet aggregation activity in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angelica sinensis / chemistry*
  • Animals
  • Anticoagulants / chemistry
  • Anticoagulants / isolation & purification*
  • Bicyclic Monoterpenes
  • Drugs, Chinese Herbal / chemistry
  • Male
  • Molecular Structure
  • Monoterpenes / chemistry
  • Monoterpenes / isolation & purification*
  • Rabbits

Substances

  • 6beta,9-dihydroxy-(+)alpha-pinene
  • 9-hydroxy-(+)-alpha-pinene-6beta-O-D-glucoside
  • Anticoagulants
  • Bicyclic Monoterpenes
  • Drugs, Chinese Herbal
  • Monoterpenes
  • alpha-pinene