Synthesis of 7,8α-dihydro-14α-deoxyecdysteroids

Rimma G Savchenko; Yana R Urasaeva; Ilgiz V Galyautdinov; Svetlana R Afonkina; Leonard M Khalilov; Fedor M Dolgushin; Victor N Odinokov

doi:10.1016/j.steroids.2011.02.027

Synthesis of 7,8α-dihydro-14α-deoxyecdysteroids

Steroids. 2011 May;76(6):603-6. doi: 10.1016/j.steroids.2011.02.027. Epub 2011 Feb 26.

Authors

Rimma G Savchenko¹, Yana R Urasaeva, Ilgiz V Galyautdinov, Svetlana R Afonkina, Leonard M Khalilov, Fedor M Dolgushin, Victor N Odinokov

Affiliation

¹ Institute of Petrochemistry and Catalysis, Russian Academy of Science, Laboratory of Organic Synthesis, Prospekt Оktyabrya 141, 450075 Ufa, Russian Federation. rimasavchenko@mail.ru

PMID: 21356225
DOI: 10.1016/j.steroids.2011.02.027

Abstract

A Pd-C-catalyzed hydrogenation in methanol and in the presence of sodium methylate is a simple, convenient and high yielding reduction method to convert the 7,14-dien-6-one ecdysteroids to their corresponding 7,8α-dihydro-14α-deoxyecdysteroids.

MeSH terms

Catalysis
Crystallography, X-Ray
Ecdysteroids / chemical synthesis*
Ecdysteroids / chemistry
Methanol / chemistry
Molecular Conformation
Oxidation-Reduction
Palladium

Substances

Ecdysteroids
Palladium
Methanol