Objective: To investigate the correlation of powder properties and formability of traditional Chinese medicine pellets prepared by extrusion/spheronization.
Method: The present effort was designed to evaluate the effects of the characters of powder on pellets formation by extrusion-spheronization, taking Danggui Buxue decoction extracts as a model drug and microcrystalline cellulose (MCC) as an ideal balling material for extrusion-spheronization.
Result: The diameter of powder had correlation with the plane critical angle of pellets in a certain scope and the sticky coefficient of wet mass affected roundness of pellets.
Conclusion: Properties of powder have influence on formability of traditional Chinese medicine pellets.