[Pharmacokinetics studies on tetramethylpyrazine by intravenous administration in rats]

Zhong Yao Cai. 2010 Oct;33(10):1599-602.
[Article in Chinese]

Abstract

Objective: To investigate the pharmacokinetics behaviour of tetramethylpyrazine (TMP) by intravenous administration in rats.

Methods: Methanol-0.05 mol/L acetate buffer solution (50:50,V/V) was used as mobile phase with a flow rate of 1.0 mL/min. The UV detection wavelength was 280 nm.

Results: The profile of TMP in blood fitted a two-compartment model. The half time of drug distribution and elimination was short. The mean residence time MRT 0-infinity was 141.61 min, and the AUC0-infinity was 7521.70 microg x min/ mL.

Conclusion: After intravenous injection, the pharmacokinetics behaviour of TMP fit a two-compartment model in rats. Both the distribution and the elimination are fast.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Area Under Curve
  • Biological Availability
  • Chromatography, High Pressure Liquid / methods
  • Drugs, Chinese Herbal / administration & dosage
  • Drugs, Chinese Herbal / pharmacokinetics*
  • Female
  • Half-Life
  • Injections
  • Ligusticum* / chemistry
  • Models, Animal
  • Molecular Structure
  • Pyrazines / administration & dosage
  • Pyrazines / blood
  • Pyrazines / pharmacokinetics*
  • Rats
  • Rats, Sprague-Dawley
  • Vasodilator Agents / administration & dosage
  • Vasodilator Agents / blood
  • Vasodilator Agents / pharmacokinetics*

Substances

  • Drugs, Chinese Herbal
  • Pyrazines
  • Vasodilator Agents
  • tetramethylpyrazine