Yersinia pseudotuberculosis is resistant to killing by human neutrophils

Thomas R Laws; Martin S Davey; Christopher Green; Ian A M Cooper; Richard W Titball; Roman A Lukaszewski

doi:10.1016/j.micinf.2011.02.004

Yersinia pseudotuberculosis is resistant to killing by human neutrophils

Microbes Infect. 2011 Jun;13(6):607-11. doi: 10.1016/j.micinf.2011.02.004. Epub 2011 Feb 24.

Authors

Thomas R Laws¹, Martin S Davey, Christopher Green, Ian A M Cooper, Richard W Titball, Roman A Lukaszewski

Affiliation

¹ Defence Science and Technology Laboratory, Salisbury, Wiltshire SP4 OJQ, UK. trlaws@dstl.gov.uk

PMID: 21354325
DOI: 10.1016/j.micinf.2011.02.004

Abstract

The interaction between human neutrophils and the Gram negative gastrointestinal pathogen Yersinia pseudotuberculosis was investigated in vitro. Despite the wealth of data describing how Yersinia can affect the function of neutrophils, there are no published studies describing if neutrophil cells can affect the viability of Y. pseudotuberculosis. The wild-type IP32953 strain of Y. pseudotuberculosis was found to be resistant to killing by human neutrophils. Confocal examination and flow-cytometric analysis of this interaction revealed that bacteria were taken up.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Endocytosis
Flow Cytometry
Humans
Microbial Viability*
Microscopy, Confocal
Neutrophils / immunology*
Yersinia pseudotuberculosis / immunology*