Abstract
A novel alkaloid, aristopyridinone A (1) and a new phenanthrene, aristolamide II (2), were isolated from Aristolochia manshuriensis (Guanmutong) together with eight known phenanthrenes (3-10). All structures were elucidated by spectroscopic methods. Compound 2 showed a selective inhibitory effect on elastase release by human neutrophils in response to fMLP with an IC(50) value of 4.11 μg/mL. Compound 7 exhibited significant inhibitory effects on superoxide anion generation and elastase release with IC(50) values of 0.12 and 0.20 μg/mL, respectively.
Copyright © 2011. Published by Elsevier Ltd.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification*
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Anti-Inflammatory Agents / pharmacology
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Aristolochia / chemistry*
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Biphenyl Compounds / chemistry
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Biphenyl Compounds / isolation & purification*
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Biphenyl Compounds / pharmacology
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Cell Line, Tumor
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Ethers / chemistry
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Ethers / isolation & purification*
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Ethers / pharmacology
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Humans
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Inhibitory Concentration 50
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Leukocyte Elastase / metabolism
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N-Formylmethionine Leucyl-Phenylalanine / pharmacology
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Neutrophils / drug effects*
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Neutrophils / enzymology
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Quinolines / chemistry
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Quinolines / isolation & purification*
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Quinolines / pharmacology
Substances
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Anti-Inflammatory Agents
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Biphenyl Compounds
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Ethers
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Quinolines
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aristoquinoline A
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N-Formylmethionine Leucyl-Phenylalanine
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Leukocyte Elastase