A novel alkaloid, aristopyridinone A and anti-inflammatory phenanthrenes isolated from Aristolochia manshuriensis

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1792-4. doi: 10.1016/j.bmcl.2011.01.067. Epub 2011 Jan 22.

Abstract

A novel alkaloid, aristopyridinone A (1) and a new phenanthrene, aristolamide II (2), were isolated from Aristolochia manshuriensis (Guanmutong) together with eight known phenanthrenes (3-10). All structures were elucidated by spectroscopic methods. Compound 2 showed a selective inhibitory effect on elastase release by human neutrophils in response to fMLP with an IC(50) value of 4.11 μg/mL. Compound 7 exhibited significant inhibitory effects on superoxide anion generation and elastase release with IC(50) values of 0.12 and 0.20 μg/mL, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / isolation & purification*
  • Anti-Inflammatory Agents / pharmacology
  • Aristolochia / chemistry*
  • Biphenyl Compounds / chemistry
  • Biphenyl Compounds / isolation & purification*
  • Biphenyl Compounds / pharmacology
  • Cell Line, Tumor
  • Ethers / chemistry
  • Ethers / isolation & purification*
  • Ethers / pharmacology
  • Humans
  • Inhibitory Concentration 50
  • Leukocyte Elastase / metabolism
  • N-Formylmethionine Leucyl-Phenylalanine / pharmacology
  • Neutrophils / drug effects*
  • Neutrophils / enzymology
  • Quinolines / chemistry
  • Quinolines / isolation & purification*
  • Quinolines / pharmacology

Substances

  • Anti-Inflammatory Agents
  • Biphenyl Compounds
  • Ethers
  • Quinolines
  • aristoquinoline A
  • N-Formylmethionine Leucyl-Phenylalanine
  • Leukocyte Elastase