Abstract
HIV-1 integrase (IN) is an essential enzyme for retroviral replication. There is no analogue for this enzyme in human cells so that inhibition of IN will not bring strong effect on human body. Thus, HIV-1 IN has become a rational target for therapy of AIDS. This review provides a comprehensive report of alpha, gamma-diketo IN inhibitors discovered in recent years. Compilation of such data will prove to be beneficial in developing QSAR, pharmacophore hypothesis generation and validation, virtual screening and synthesis of compounds with higher activity.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anti-HIV Agents* / chemical synthesis
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Anti-HIV Agents* / chemistry
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Anti-HIV Agents* / pharmacology
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HIV Integrase / chemistry
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HIV Integrase / physiology
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HIV Integrase Inhibitors* / chemical synthesis
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HIV Integrase Inhibitors* / chemistry
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HIV Integrase Inhibitors* / pharmacology
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HIV-1 / drug effects*
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Humans
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Keto Acids* / chemical synthesis
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Keto Acids* / chemistry
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Keto Acids* / pharmacology
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Molecular Structure
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Quantitative Structure-Activity Relationship
Substances
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Anti-HIV Agents
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HIV Integrase Inhibitors
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Keto Acids
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HIV Integrase