Unique X-ray sheet structure of 1,8-bis(imidazolium) anthracene and its application as a fluorescent probe for DNA and DNase

Org Lett. 2011 Mar 18;13(6):1314-7. doi: 10.1021/ol103166q. Epub 2011 Feb 24.

Abstract

A new imidazolium anthracene derivative 1 was synthesized, and its unique X-ray crystal structure was examined. In aqueous solutions, probe 1 exhibited a selective fluorescent quenching effect only with DNA among various anions including the nucleotides investigated. This probe was further applied to monitor the activity of DNase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthracenes / chemical synthesis*
  • Anthracenes / chemistry
  • Crystallography, X-Ray
  • DNA / analysis*
  • DNA / chemistry
  • Deoxyribonucleases / analysis*
  • Deoxyribonucleases / metabolism
  • Fluorescent Dyes / chemical synthesis*
  • Fluorescent Dyes / chemistry
  • Imidazoles / chemical synthesis*
  • Imidazoles / chemistry
  • Molecular Conformation
  • Molecular Structure

Substances

  • 1,8-bis(imidazolium)anthracene
  • Anthracenes
  • Fluorescent Dyes
  • Imidazoles
  • DNA
  • Deoxyribonucleases