Henrischinins A-C: three new triterpenoids from Schisandra henryi

Org Lett. 2011 Mar 18;13(6):1564-7. doi: 10.1021/ol200283y. Epub 2011 Feb 24.

Abstract

Three novel triterpenoids, henrischinins A-C (1-3), featuring the unique motif of a 3-one-2-oxabicyclo[3.2.1]-octane, were isolated from the leaves and stems of Schisandra henryi. Their structures were elucidated by spectroscopic methods, and the absolute configuration of 2 was confirmed by a single crystal X-ray diffraction. Compounds 1 and 2 showed weak cytotoxicity against HL-60 cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Crystallography, X-Ray
  • Drug Screening Assays, Antitumor
  • HL-60 Cells
  • Humans
  • Molecular Conformation
  • Molecular Structure
  • Plant Leaves / chemistry
  • Plant Stems / chemistry
  • Schisandra / chemistry*
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology

Substances

  • Antineoplastic Agents, Phytogenic
  • Triterpenes
  • henrischinin A
  • henrischinin B
  • henrischinin C