Genetic comparison of human alphaherpesvirus genomes

Joel D. Baines; Philip E. Pellett

Genetic comparison of human alphaherpesvirus genomes

Review

In: Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge: Cambridge University Press; 2007. Chapter 5.

Authors

Joel D. Baines¹, Philip E. Pellett²

Book Editors

Ann Arvin¹, Gabriella Campadelli-Fiume², Edward Mocarski³, Patrick S. Moore⁴, Bernard Roizman⁵, Richard Whitley⁶, Koichi Yamanishi⁷

Affiliations

¹ College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
² Lerner Research Institute, The Cleveland Clinic, Cleveland, OH, USA

Book Affiliations

¹ Stanford University, CA School of Medicine
² University of Bologna, Italy
³ Emory University School of Medicine, USA
⁴ University of Pittsburgh Cancer Institute, PA, USA
⁵ The University of Chicago, IL, USA
⁶ University of Alabama at Birmingham, AL, USA
⁷ Osaka University School of Medicine, Japan

PMID: 21348084
Bookshelf ID: NBK47393

Excerpt

Human herpesviruses 1, 2, and 3 (herpes simplex virus 1 (HSV-1), herpes simplex virus 2 (HSV-2), and varicella-zoster virus (VZV)) have been classified as alphaherpesviruses based originally upon their biological properties, and subsequently on the sequences of their respective genomes (Minson et al., ; Pellett and Roizman, in press). All of these viruses maintain latent infections in sensory ganglia, and can productively infect a variety of human cells, including the living cells of mucous membranes and skin. These epithelial sites also provide exit points for the virus to infect other individuals.

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