Abstract
A new aporphine alkaloid, (-)-arcabucoine [(6aR)-N-formyl-1,2-methylenedioxy-9,10-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline] 1 was isolated from the leaves of Talauma arcabucoana (Magnoliaceae), along with the known compounds (-)-erythro-saccharinic acid lactone 2 and (-)-shikimic acid 3. Furthermore, the known aporphine alkaloids (-)-dicentrine 4, (-)-nordicentrine 5 and dicentrinone 6 were isolated from the stem bark. The alkaloids 4 and 5 were found to be the most active compounds in a brine shrimp lethality assay. In addition, alkaloids 1, 4 and 5 showed moderate growth inhibition against Staphylococcus aureus and Candida albicans.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology
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Aporphines / chemistry*
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Aporphines / isolation & purification*
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Aporphines / pharmacology*
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Artemia / drug effects*
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Candida albicans / drug effects
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Escherichia coli / drug effects
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Magnoliaceae / chemistry*
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Microbial Sensitivity Tests
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Plant Extracts* / chemistry
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Plant Extracts* / pharmacology
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Plant Leaves / chemistry
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Plant Stems / chemistry
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Pseudomonas aeruginosa / drug effects
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Salmonella enterica / drug effects
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Staphylococcus aureus / drug effects
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Toxicity Tests / methods*
Substances
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Anti-Infective Agents
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Aporphines
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Plant Extracts
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arcabucoine