Bench-to-bedside review: the role of C1-esterase inhibitor in sepsis and other critical illnesses

Mervyn Singer; Annie M Jones

doi:10.1186/cc9304

Bench-to-bedside review: the role of C1-esterase inhibitor in sepsis and other critical illnesses

Crit Care. 2011 Jan 26;15(1):203. doi: 10.1186/cc9304.

Authors

Mervyn Singer¹, Annie M Jones

Affiliation

¹ Bloomsbury Institute of Intensive Care Medicine, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK. m.singer@ucl.ac.uk

PMID: 21345278
PMCID: PMC3222011
DOI: 10.1186/cc9304

Abstract

The purpose of this bench-to-bedside review is to summarize the literature relating to complement activation in sepsis and other critical illnesses and the role of C1-esterase inhibitor (C1 INH) as a potential therapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Complement C1 Inhibitor Protein / physiology
Complement C1 Inhibitor Protein / therapeutic use*
Complement Pathway, Classical / immunology
Critical Illness / therapy*
Disease Models, Animal
Humans
Point-of-Care Systems* / trends
Sepsis / drug therapy*
Sepsis / immunology
Sepsis / pathology

Substances

Anti-Inflammatory Agents, Non-Steroidal
Complement C1 Inhibitor Protein