Treatment of candidemia in adult patients without neutropenia--an inconvenient truth

Crit Care. 2011;15(1):114. doi: 10.1186/cc9414. Epub 2011 Jan 31.

Abstract

In 2009 the Infectious Diseases Society of America reviewed the guidelines on the treatment of candidemia in non-neutropenic patients. In this document the preferred treatment was either fluconazole or an echinocandin. Amphotericin-B formulations were considered an alternative. However, careful assessment of published data showed similar efficacy between these drugs.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Amphotericin B / adverse effects
  • Amphotericin B / therapeutic use
  • Animals
  • Antifungal Agents / adverse effects
  • Antifungal Agents / therapeutic use*
  • Candidemia / drug therapy*
  • Candidemia / epidemiology
  • Echinocandins / adverse effects
  • Echinocandins / therapeutic use
  • Fluconazole / adverse effects
  • Fluconazole / therapeutic use
  • Fungal Proteins / adverse effects
  • Fungal Proteins / therapeutic use
  • Humans
  • Kidney Diseases / chemically induced
  • Kidney Diseases / epidemiology
  • Neutropenia*
  • Practice Guidelines as Topic / standards*
  • Treatment Outcome

Substances

  • Antifungal Agents
  • Echinocandins
  • Fungal Proteins
  • Amphotericin B
  • Fluconazole
  • echinocandin B