Abstract
Five new sesterterpenes (7-11) along with six known compounds (1-6) were isolated from the sponge Hyatella sp., collected off the coast of Soheuksan-do, Korea. Spectroscopic analyses revealed these compounds as scalarane sesterterpenes with oxidized furan moieties (7-10) and a corresponding lactam (11). The compounds exhibited moderate cytotoxicity, antibacterial activity, and weak inhibitory activity against isocitrate lyase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Bacillus subtilis / drug effects
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Democratic People's Republic of Korea
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Drug Screening Assays, Antitumor
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Escherichia coli / drug effects
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Isocitrate Lyase / antagonists & inhibitors
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Microbial Sensitivity Tests
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Micrococcus / drug effects
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Molecular Structure
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Porifera / chemistry*
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Proteus vulgaris / drug effects
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Salmonella typhimurium / drug effects
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Sesterterpenes / chemistry
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Sesterterpenes / isolation & purification*
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Sesterterpenes / pharmacology
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Sesterterpenes
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Isocitrate Lyase