Scalarane sesterterpenes from the sponge Hyatella sp

J Nat Prod. 2011 Apr 25;74(4):847-51. doi: 10.1021/np1006873. Epub 2011 Feb 22.

Abstract

Five new sesterterpenes (7-11) along with six known compounds (1-6) were isolated from the sponge Hyatella sp., collected off the coast of Soheuksan-do, Korea. Spectroscopic analyses revealed these compounds as scalarane sesterterpenes with oxidized furan moieties (7-10) and a corresponding lactam (11). The compounds exhibited moderate cytotoxicity, antibacterial activity, and weak inhibitory activity against isocitrate lyase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Bacillus subtilis / drug effects
  • Democratic People's Republic of Korea
  • Drug Screening Assays, Antitumor
  • Escherichia coli / drug effects
  • Isocitrate Lyase / antagonists & inhibitors
  • Microbial Sensitivity Tests
  • Micrococcus / drug effects
  • Molecular Structure
  • Porifera / chemistry*
  • Proteus vulgaris / drug effects
  • Salmonella typhimurium / drug effects
  • Sesterterpenes / chemistry
  • Sesterterpenes / isolation & purification*
  • Sesterterpenes / pharmacology
  • Staphylococcus aureus / drug effects

Substances

  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Sesterterpenes
  • Isocitrate Lyase