Abstract
Two new eunicellin-type diterpenoids, cladielloides A (1) and B (2), which were found to possess a 2-hydroxybutyroxy group in their structures, were isolated from an Indonesian octocoral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods. Cladielloide B (2) exhibited moderate cytotoxicity toward CCRF-CEM tumor cells and this compound displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils.
Keywords:
cladielloide; cytotoxicity; elastase; eunicellin; octocoral; superoxide anion.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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HL-60 Cells
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Humans
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Indonesia
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Leukemia P388
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Leukocyte Elastase / metabolism
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Molecular Structure
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Neutrophils / drug effects
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Neutrophils / metabolism
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Superoxides / metabolism
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Antineoplastic Agents
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Diterpenes
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cladielloide A
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cladielloide B
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eunicellin
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Superoxides
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Leukocyte Elastase