Cladielloides A and B: new eunicellin-type diterpenoids from an Indonesian octocoral Cladiella sp

Mar Drugs. 2010 Dec 6;8(12):2936-45. doi: 10.3390/md8122936.

Abstract

Two new eunicellin-type diterpenoids, cladielloides A (1) and B (2), which were found to possess a 2-hydroxybutyroxy group in their structures, were isolated from an Indonesian octocoral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods. Cladielloide B (2) exhibited moderate cytotoxicity toward CCRF-CEM tumor cells and this compound displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils.

Keywords: cladielloide; cytotoxicity; elastase; eunicellin; octocoral; superoxide anion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology*
  • HL-60 Cells
  • Humans
  • Indonesia
  • Leukemia P388
  • Leukocyte Elastase / metabolism
  • Molecular Structure
  • Neutrophils / drug effects
  • Neutrophils / metabolism
  • Superoxides / metabolism

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antineoplastic Agents
  • Diterpenes
  • cladielloide A
  • cladielloide B
  • eunicellin
  • Superoxides
  • Leukocyte Elastase