Molecular and genetic analysis of NS gene from high pathogenic strains of the avian influenza (H5N1) virus isolated in Kazakhstan

Olga V Chervyakova; Vitaliy M Strochkov; Kulyaisan T Sultankulova; Nurlan T Sandybayev; Valentin L Zaitsev; Seidigapbar M Mamadaliyev

doi:10.1016/j.gene.2011.02.003

Molecular and genetic analysis of NS gene from high pathogenic strains of the avian influenza (H5N1) virus isolated in Kazakhstan

Gene. 2011 May 1;476(1-2):15-9. doi: 10.1016/j.gene.2011.02.003. Epub 2011 Feb 19.

Authors

Olga V Chervyakova¹, Vitaliy M Strochkov, Kulyaisan T Sultankulova, Nurlan T Sandybayev, Valentin L Zaitsev, Seidigapbar M Mamadaliyev

Affiliation

¹ Research Institute for Biological Safety Problems, RK ME&S–Science Committee, Gvardeiskiy, Kordaiskiy rayon, Zhambylskaya oblast, 080409, Republic of Kazakhstan. chervyakova@srai.kz

PMID: 21338659
DOI: 10.1016/j.gene.2011.02.003

Abstract

The high pathogenic strains of the avian influenza H5N1 virus isolated in Kazakhstan have NS of different genotypes. The influenza virus strains isolated in 2005 is of NS1E Qinghai genotype. A/swan/Mangystau/3/2006 strain is of NS2A genotype that is typical for Gs/Gd-like strains. The results of the analysis allow assuming that A/swan/Mangystau/3/2006 strain has been brought onto the territory of Kazakhstan from the European part of the continent along the Black Sea-Mediterranean flyway.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animal Migration
Animals
Anseriformes / virology
Chickens / virology
Geese / virology
Genes, Viral*
Influenza A Virus, H5N1 Subtype / genetics*
Influenza A Virus, H5N1 Subtype / isolation & purification
Influenza A Virus, H5N1 Subtype / pathogenicity
Influenza in Birds / virology*
Kazakhstan
Phylogeny
Viral Nonstructural Proteins / genetics*
Virulence / genetics

Substances

NS2 protein, influenza virus A
Viral Nonstructural Proteins