Correlation of Ochratoxin A exposure to urinary levels of 8-hydroxydeoxyguanosine and malondialdehyde in a Turkish population

Bull Environ Contam Toxicol. 2011 Mar;86(3):258-62. doi: 10.1007/s00128-011-0225-z. Epub 2011 Feb 19.

Abstract

Ochratoxin A is one of the most abundant food- contaminating mycotoxins in the world that is immunosuppressive, genotoxic, teratogenic and carcinogenic. Malondialdehyde is a naturally occurring product of lipid peroxidation that is mutagenic and carcinogenic. 8-Hydroxydeoxyguanosine is produced during the interaction of reactive oxygen species and DNA. In this study, Ochratoxin A, malondialdehyde and 8-Hydroxydeoxyguanosine levels of individuals in the study group were measured and results were correlated with each other. Additionally, the correlation of biomarker levels to smoking habit, alcohol and coffee consumption, age and gender of individuals was investigated. As a result of these assessments, a significant correlation was observed between Ochratoxin A exposures and malondialdehyde and 8-Hydroxydeoxyguanosine levels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 8-Hydroxy-2'-Deoxyguanosine
  • Adult
  • Biomarkers / urine
  • Creatinine / urine
  • Deoxyguanosine / analogs & derivatives*
  • Deoxyguanosine / urine
  • Environmental Exposure / analysis
  • Environmental Exposure / statistics & numerical data
  • Female
  • Humans
  • Male
  • Malondialdehyde / urine*
  • Ochratoxins / urine*
  • Turkey

Substances

  • Biomarkers
  • Ochratoxins
  • ochratoxin A
  • Malondialdehyde
  • 8-Hydroxy-2'-Deoxyguanosine
  • Creatinine
  • Deoxyguanosine