Abstract
A series of 2-aminofluorenes N-alkylated with nitroxides or their precursors were synthesized. The new compounds were tested on hydroxyl radical and peroxyl radical scavenging ability and inflammatory assay on the endothelial brain cells. In agreement with ROS scavenging ability the same compound 7-bromo-N -[(1-Oxyl-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine-4yl)methyl]-9H-fluoren-2-amine (3b) and its hydroxylamine salt (3b/OH/HCl) showed the anti-inflammatory property on the endothelial brain cells.
Copyright © 2011. Published by Elsevier Masson SAS.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amyloid / chemistry*
-
Cell Line
-
Electron Spin Resonance Spectroscopy
-
Endothelial Cells / drug effects
-
Endothelial Cells / metabolism
-
Fluorenes / chemical synthesis*
-
Fluorenes / chemistry
-
Fluorenes / pharmacology*
-
Free Radical Scavengers / chemical synthesis*
-
Free Radical Scavengers / chemistry
-
Free Radical Scavengers / pharmacology*
-
Humans
-
Hydroxyl Radical / chemistry
-
Lipolysis / drug effects
-
Nitrogen Oxides / chemistry*
-
Peroxides / chemistry
-
Protein Multimerization / drug effects*
-
Protein Structure, Secondary
Substances
-
Amyloid
-
Fluorenes
-
Free Radical Scavengers
-
Nitrogen Oxides
-
Peroxides
-
perhydroxyl radical
-
Hydroxyl Radical
-
nitroxyl