Yin Yang 1: a multifaceted protein beyond a transcription factor

Transcription. 2010 Sep-Oct;1(2):81-4. doi: 10.4161/trns.1.2.12375.

Abstract

As a transcription factor, Yin Yang 1 (YY1) regulates the transcription of a dazzling list of genes and the number of its targets still mounts. Recent studies revealed that YY1 possesses functions independent of its DNA binding activity and its regulatory role in tumorigenesis has started to emerge.

Keywords: Yin Yang 1; androgen receptor; coactivator; prostate cancer; protein modification; transcription factor.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Male
  • Models, Genetic
  • Prostatic Neoplasms / genetics*
  • Prostatic Neoplasms / pathology
  • Trans-Activators / genetics
  • Trans-Activators / metabolism
  • Transcription, Genetic / genetics*
  • YY1 Transcription Factor / genetics*
  • YY1 Transcription Factor / metabolism*

Substances

  • Trans-Activators
  • YY1 Transcription Factor