Synthetic studies toward A-74528

Org Lett. 2011 Mar 18;13(6):1386-9. doi: 10.1021/ol103117j. Epub 2011 Feb 16.

Abstract

A potentially biomimetic approach toward the complex polyketide A-74528 is described. It is based on highly substituted biaryl compounds, synthesized using advanced cross-coupling and condensation methodologies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Products / chemical synthesis*
  • Biological Products / chemistry
  • Catalysis
  • Cyclization
  • Molecular Structure
  • Polycyclic Compounds / chemical synthesis*
  • Polycyclic Compounds / chemistry
  • Pyrones / chemical synthesis*
  • Pyrones / chemistry
  • Stereoisomerism
  • Streptomyces / chemistry

Substances

  • A-74528
  • Biological Products
  • Polycyclic Compounds
  • Pyrones