Abstract
This Article describes the total synthesis of the marine ladder toxin brevenal utilizing a convergent synthetic strategy. Critical to the success of this work was the use of olefinic-ester cyclization reactions and the utilization of glycal epoxides as precursors to C-C and C-H bonds.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Alkenes / chemistry
-
Cyclization
-
Dinoflagellida / chemistry*
-
Epoxy Compounds / chemistry
-
Ethers / chemical synthesis*
-
Marine Toxins / chemical synthesis
-
Polymers / chemical synthesis*
Substances
-
Alkenes
-
Epoxy Compounds
-
Ethers
-
Marine Toxins
-
Polymers
-
brevenal (polyether)