Redox strategy for reversible attachment of biomolecules using bifunctional linkers

Galina V Dubacheva; Mathieu Galibert; Liliane Coche-Guerente; Pascal Dumy; Didier Boturyn; Pierre Labbé

doi:10.1039/c0cc05647b

Redox strategy for reversible attachment of biomolecules using bifunctional linkers

Chem Commun (Camb). 2011 Mar 28;47(12):3565-7. doi: 10.1039/c0cc05647b. Epub 2011 Feb 15.

Authors

Galina V Dubacheva¹, Mathieu Galibert, Liliane Coche-Guerente, Pascal Dumy, Didier Boturyn, Pierre Labbé

Affiliation

¹ Département de Chimie Moléculaire, UMR CNRS 5250, Université Joseph Fourier, ICMG FR CNRS 2607, BP53, 38041 Grenoble cedex 9, France. galina.dubacheva@ujf-grenoble.fr

PMID: 21321707
DOI: 10.1039/c0cc05647b

Abstract

Soft attachment of streptavidin to β-cyclodextrin-modified pegylated SAMs was efficiently performed in a reversible and repetitive way via orthogonal bifunctional linkers involving streptavidin-biotin recognition and redox-driven multivalent host-guest (β-cyclodextrin-ferrocene) interactions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cross-Linking Reagents / chemical synthesis
Cross-Linking Reagents / chemistry*
Ferrous Compounds / chemistry
Metallocenes
Oxidation-Reduction
Streptavidin / chemistry*
Streptavidin / metabolism
beta-Cyclodextrins / chemistry*
beta-Cyclodextrins / metabolism

Substances

Cross-Linking Reagents
Ferrous Compounds
Metallocenes
beta-Cyclodextrins
Streptavidin
ferrocene