A novel pH-responsive polysaccharidic ionic complex for proapoptotic D-(KLAKLAK)2 peptide delivery

Chem Commun (Camb). 2011 Apr 7;47(13):3852-4. doi: 10.1039/c0cc03590d. Epub 2011 Feb 14.

Abstract

We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as 'GCS-g-DMA' hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / therapeutic use
  • Chitosan / chemistry*
  • Drug Carriers / chemistry*
  • Female
  • Humans
  • Hydrogen-Ion Concentration
  • Maleates / chemistry*
  • Melanoma, Experimental / drug therapy
  • Mice
  • Neoplasms / drug therapy*
  • Peptides / administration & dosage*
  • Peptides / therapeutic use

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Maleates
  • Peptides
  • glycol-chitosan
  • Chitosan
  • dimethyl maleate