Abstract
We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as 'GCS-g-DMA' hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / therapeutic use
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Chitosan / chemistry*
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Drug Carriers / chemistry*
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Female
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Humans
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Hydrogen-Ion Concentration
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Maleates / chemistry*
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Melanoma, Experimental / drug therapy
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Mice
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Neoplasms / drug therapy*
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Peptides / administration & dosage*
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Peptides / therapeutic use
Substances
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Antineoplastic Agents
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Drug Carriers
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Maleates
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Peptides
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glycol-chitosan
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Chitosan
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dimethyl maleate