Polymorphisms of the vascular endothelial growth factor A gene and susceptibility to sporadic brain arteriovenous malformation in a Chinese population

Hongyan Chen; Yuxiang Gu; Wenting Wu; Dan Chen; Peiliang Li; Weiwei Fan; Daru Lu; Fan Zhao; Nidan Qiao; Huijia Qiu; Chaowei Fu; Ying Mao; Yao Zhao

doi:10.1016/j.jocn.2010.08.025

Polymorphisms of the vascular endothelial growth factor A gene and susceptibility to sporadic brain arteriovenous malformation in a Chinese population

J Clin Neurosci. 2011 Apr;18(4):549-53. doi: 10.1016/j.jocn.2010.08.025. Epub 2011 Feb 12.

Authors

Hongyan Chen¹, Yuxiang Gu, Wenting Wu, Dan Chen, Peiliang Li, Weiwei Fan, Daru Lu, Fan Zhao, Nidan Qiao, Huijia Qiu, Chaowei Fu, Ying Mao, Yao Zhao

Affiliation

¹ State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.

PMID: 21316969
DOI: 10.1016/j.jocn.2010.08.025

Abstract

Human brain arteriovenous malformation (BAVM) tissue contains increased levels of vascular endothelial growth factor A (VEGFA). We carried out a case-control study to determine whether polymorphisms in the VEGFA gene are associated with sporadic BAVM. Nine selected VEGFA single-nucleotide polymorphisms (SNP) were genotyped in 319 patients with BAVM and 333 controls from a Chinese population using the MassARRAY genotyping system. We found four single variants in the VEGFA gene (rs1547651, rs2010963, rs833069 and rs3025010), with one haplotype, ACT, possibly associated with the risk of developing BAVM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Asian People / genetics
Case-Control Studies
Female
Gene Frequency
Genetic Predisposition to Disease / genetics*
Genotype
Humans
Intracranial Arteriovenous Malformations / genetics*
Male
Polymerase Chain Reaction
Polymorphism, Single Nucleotide*
Vascular Endothelial Growth Factor A / genetics*

Substances

Vascular Endothelial Growth Factor A