The effect of local breast radiotherapy on circulating CD34(+) cells

Nehad M Alajez; Wei Wang; Debashis Biswas; Amy Teh; Robert Sutherland; Melania Pintilie; Mark Minden; Hans Messner; Anthony Fyles; Mary Gospodarowicz; Armand Keating; Fei-Fei Liu

doi:10.1016/j.radonc.2011.01.003

The effect of local breast radiotherapy on circulating CD34(+) cells

Radiother Oncol. 2011 Aug;100(2):304-7. doi: 10.1016/j.radonc.2011.01.003. Epub 2011 Feb 11.

Authors

Nehad M Alajez¹, Wei Wang, Debashis Biswas, Amy Teh, Robert Sutherland, Melania Pintilie, Mark Minden, Hans Messner, Anthony Fyles, Mary Gospodarowicz, Armand Keating, Fei-Fei Liu

Affiliation

¹ Ontario Cancer Institute, Toronto, Canada.

PMID: 21316784
DOI: 10.1016/j.radonc.2011.01.003

Abstract

The number of circulating CD34(+) (hematopoietic stem) cells (HSCs) was observed to decline by 15% in breast cancer patients after starting adjuvant radiation therapy, regardless of age or preceding chemotherapy. These data demonstrate that local radiation therapy can profoundly affect HSC homeostasis, which might have a myriad of important implications.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Antigens, CD34 / analysis*
Breast Neoplasms / blood
Breast Neoplasms / drug therapy
Breast Neoplasms / radiotherapy*
Female
Hematopoietic Stem Cells / radiation effects*
Humans
Middle Aged

Substances

Antigens, CD34