Physical and chemical stability of drug nanoparticles

Adv Drug Deliv Rev. 2011 May 30;63(6):456-69. doi: 10.1016/j.addr.2011.02.001. Epub 2011 Feb 21.

Abstract

As nano-sizing is becoming a more common approach for pharmaceutical product development, researchers are taking advantage of the unique inherent properties of nanoparticles for a wide variety of applications. This article reviews the physical and chemical stability of drug nanoparticles, including their mechanisms and corresponding characterization techniques. A few common strategies to overcome stability issues are also discussed.

Publication types

  • Review

MeSH terms

  • Drug Delivery Systems / methods*
  • Drug Stability
  • Nanoparticles / administration & dosage
  • Nanoparticles / chemistry*
  • Pharmaceutical Preparations / administration & dosage
  • Pharmaceutical Preparations / chemistry*

Substances

  • Pharmaceutical Preparations