Silicon-based chemistry: an original and efficient one-step approach to [18F]-nucleosides and [18F]-oligonucleotides for PET imaging

Chemistry. 2011 Mar 7;17(11):3096-100. doi: 10.1002/chem.201003234. Epub 2011 Feb 10.

Abstract

Take it eaSi! Nucleosides, dinucleotides, and one oligonucleotide, all modified by click chemistry, have for the first time been directly and very efficiently labeled with (18)F by using a silicon-based, one-step approach that opens the way for the development of a new class of positron emission tomography (PET) tracers (see graphic).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Click Chemistry
  • Fluorine Radioisotopes / chemistry
  • Oligonucleotides / chemistry*
  • Positron-Emission Tomography
  • Radiopharmaceuticals / chemistry*
  • Silicon / chemistry*

Substances

  • Fluorine Radioisotopes
  • Oligonucleotides
  • Radiopharmaceuticals
  • Silicon