A 'Sleeping Trojan Horse' which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging

Flora L Thorp-Greenwood; Vanesa Fernández-Moreira; Coralie O Millet; Catrin F Williams; Joanne Cable; Jonathan B Court; Anthony J Hayes; David Lloyd; Michael P Coogan

doi:10.1039/c1cc10141b

A 'Sleeping Trojan Horse' which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging

Chem Commun (Camb). 2011 Mar 21;47(11):3096-8. doi: 10.1039/c1cc10141b. Epub 2011 Feb 11.

Authors

Flora L Thorp-Greenwood¹, Vanesa Fernández-Moreira, Coralie O Millet, Catrin F Williams, Joanne Cable, Jonathan B Court, Anthony J Hayes, David Lloyd, Michael P Coogan

Affiliation

¹ Department of Chemistry, Cardiff University, Cardiff, Cymru/Wales, UK CF10 3AT.

PMID: 21311811
DOI: 10.1039/c1cc10141b

Abstract

A rhenium polypyridine-based molecular vessel is membrane impermeant when empty, but, upon loading with metal ions, the cationic form is taken up by MCF-7 cells, localising in nucleoli. The luminescence of the vessel and its copper binding ability suggest potential as a bimodal fluorescence/PET imaging agent.

MeSH terms

Biological Transport
Cell Line, Tumor
Cell Nucleolus / metabolism*
Coordination Complexes / chemistry*
Copper / chemistry
Fluorescent Dyes / chemistry*
Humans
Ions / chemistry
Metals / chemistry*
Organometallic Compounds / chemistry*
Positron-Emission Tomography
Rhenium / chemistry
Silver / chemistry

Substances

Coordination Complexes
Fluorescent Dyes
Ions
Metals
Organometallic Compounds
Silver
Rhenium
Copper