Chronic interstitial nephritis in an HIV type-1-infected patient receiving ritonavir-boosted atazanavir

Antivir Ther. 2011;16(1):119-21. doi: 10.3851/IMP1700.

Abstract

Here, we report a case of chronic granulomatous tubulo-interstitial nephritis related to atazanavir crystals in a HIV type-1-infected patient. Renal function in this patient was partially recovered after atazanavir withdrawal and steroid therapy. Many reports have described atazanavir-associated urolithiasis, but this is the first case that describes chronic granulomatous nephropathy.

Publication types

  • Case Reports

MeSH terms

  • Africa, Northern / ethnology
  • Atazanavir Sulfate
  • Crystallization
  • Drug Therapy, Combination / adverse effects*
  • France
  • Granulomatous Disease, Chronic / chemically induced*
  • Granulomatous Disease, Chronic / physiopathology
  • HIV Infections / drug therapy
  • HIV Infections / pathology
  • HIV Protease Inhibitors / administration & dosage
  • HIV Protease Inhibitors / adverse effects*
  • HIV-1*
  • Humans
  • Male
  • Middle Aged
  • Nephritis, Interstitial / chemically induced*
  • Nephritis, Interstitial / physiopathology
  • Oligopeptides / administration & dosage
  • Oligopeptides / adverse effects*
  • Pyridines / administration & dosage
  • Pyridines / adverse effects*
  • Ritonavir / administration & dosage
  • Ritonavir / therapeutic use

Substances

  • HIV Protease Inhibitors
  • Oligopeptides
  • Pyridines
  • Atazanavir Sulfate
  • Ritonavir