Abstract
The highly enantioselective catalytic asymmetric addition of aryl and alkenylboronic acids to N-benzylnicotinate salt 1 is described. The dihydropyridine 2 reaction products can be converted to synthetically useful piperidines. Application of the methodology to the preparation of enantioenriched quaternary chiral centers is also discussed.
MeSH terms
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Boronic Acids / chemical synthesis
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Boronic Acids / chemistry*
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Catalysis
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Molecular Structure
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Nicotinic Acids / chemical synthesis
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Nicotinic Acids / chemistry*
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Rhodium / chemistry*
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Salts / chemical synthesis
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Salts / chemistry
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Stereoisomerism
Substances
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Boronic Acids
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Nicotinic Acids
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Salts
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Rhodium
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nicotinic acid benzyl ester