Synthesis of chroman aldehydes that inhibit HIV

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1399-401. doi: 10.1016/j.bmcl.2011.01.031. Epub 2011 Jan 14.

Abstract

Chroman aldehydes bearing an acetyl group plus alkoxyl or hydroxyl groups inhibit HIV infectivity in HeLa37 cells.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aldehydes / chemical synthesis*
  • Aldehydes / chemistry
  • Aldehydes / pharmacology*
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Cell Line
  • Chromans / chemical synthesis*
  • Chromans / chemistry
  • Chromans / pharmacology*
  • HIV / drug effects*
  • HIV Infections / drug therapy
  • Humans
  • Inhibitory Concentration 50
  • Molecular Structure

Substances

  • Aldehydes
  • Antiviral Agents
  • Chromans