Abstract
A series of d((5')TGGGAG(3')) sequences, 5'-conjugated with a variety of aromatic groups through phosphodiester linkages, were synthesized, showing CD spectra diagnostic of parallel-stranded, tetramolecular G-quadruplex structures. When tested for anti-HIV-1 and HIV-2 activity, potent inhibition of HIV-1 infection in CEM cell cultures was found, associated with high selectivity index values. Surface Plasmon Resonance assays revealed specific binding to HIV-1 gp120 and gp41.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemical synthesis
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Anti-HIV Agents / chemistry*
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Anti-HIV Agents / pharmacology
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Cell Line
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Drug Evaluation, Preclinical
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G-Quadruplexes*
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HIV / metabolism
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HIV Envelope Protein gp120 / chemistry
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HIV Envelope Protein gp120 / metabolism
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HIV Envelope Protein gp41 / chemistry
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HIV Envelope Protein gp41 / metabolism
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Humans
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Oligonucleotides / chemical synthesis
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Oligonucleotides / chemistry*
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Oligonucleotides / pharmacology
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Surface Plasmon Resonance
Substances
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Anti-HIV Agents
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HIV Envelope Protein gp120
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HIV Envelope Protein gp41
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Oligonucleotides