Abstract
Two new isoprenylated epoxyquinol derivatives, pestaloquinols A (2) and B (3), and their putative biosynthetic precursor, cytosporin D (1), were isolated from the crude extract of the plant endophytic fungus Pestalotiopsis sp. The structures of these compounds were elucidated primarily by NMR experiments. Pestaloquinols A (2) and B (3) possess a previously undescribed nonacyclic ring system and showed cytotoxicity against HeLa cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Benzopyrans / chemistry
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Benzopyrans / isolation & purification*
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Benzopyrans / pharmacology
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Drug Screening Assays, Antitumor
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Epoxy Compounds / chemistry
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Epoxy Compounds / isolation & purification*
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Epoxy Compounds / pharmacology
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HeLa Cells
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Humans
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Hydroquinones / chemistry
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Hydroquinones / isolation & purification*
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Hydroquinones / pharmacology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Xylariales / chemistry*
Substances
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Antineoplastic Agents
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Benzopyrans
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Epoxy Compounds
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Hydroquinones
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cytosporin D
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pestaloquinol A
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pestaloquinol B