Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana

Uraiwan Songsiang; Tula Thongthoom; Chantana Boonyarat; Chavi Yenjai

doi:10.1021/np100654m

Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana

J Nat Prod. 2011 Feb 25;74(2):208-12. doi: 10.1021/np100654m. Epub 2011 Feb 8.

Authors

Uraiwan Songsiang¹, Tula Thongthoom, Chantana Boonyarat, Chavi Yenjai

Affiliation

¹ Natural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.

PMID: 21302964
DOI: 10.1021/np100654m

Abstract

Four new carbazole alkaloids, claurailas A-D (1-4), as well as 12 known carbazoles and three known coumarins were isolated from the roots of Clausena harmandiana. Heptaphylline (6) and 7-methoxyheptaphylline (7) showed strong cytotoxicity against NCI-H187 and KB cell lines with IC(50) values ranging from 1.3 to 2.7 μM. Compound 7 showed no cytotoxicity against Vero cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification*
Alkaloids / pharmacology*
Animals
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology*
Carbazoles / chemistry
Carbazoles / isolation & purification*
Carbazoles / pharmacology*
Chlorocebus aethiops
Clausena / chemistry*
Coumarins / chemistry
Coumarins / isolation & purification*
Coumarins / pharmacology
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
KB Cells
Plant Roots / chemistry

Substances

7-methoxyheptaphylline
Alkaloids
Antineoplastic Agents, Phytogenic
Carbazoles
Coumarins
heptaphylline