Bispyribac-sodium is a commonly used herbicide. An analytical method employing HPLC with a diode array detector was developed to determine bispyribac-sodium residues in rice. The liquid-liquid partition and anion exchange solid phase procedures that were developed provide effective extraction and cleanup methods for analysis feasibility. Recoveries ranged from 83.98 to 98.51% with a relative standard deviation of 0.56-6.36% and sensitivity of 0.01 mg/kg. Bispyribac-sodium residues in rice were further confirmed by LC-MS. The proposed method was successfully applied to the analysis of bispyribac-sodium residues from a rice field in Jiangxi Province that had been treated using bispyribac-sodium.