Clinical value of (18)F-FDG PET/CT in postoperative monitoring for patients with colorectal carcinoma

Cancer Epidemiol. 2011 Oct;35(5):497-500. doi: 10.1016/j.canep.2011.01.002. Epub 2011 Feb 5.

Abstract

Objective: To evaluate the clinical value of (18)F-FDG PET/CT in postoperative monitoring for patients with colorectal carcinoma.

Methods: 66 postoperative patients with colorectal carcinoma underwent whole-body FDG PET/CT. The final histopathological and formal clinical follow-up findings were used as gold standard to determine the sensitivity and specificity of FDG PET/CT and enhanced CT of the same periods.

Results: The sensitivity and specificity of FDG PET/CT in detecting recurrence are 96.30%, 94.87% (while enhanced CT are 70.37% and 87.18% respectively). The sensitivity and specificity in detecting metastasis are 95.35%, 82.61% (enhanced CT are 61.90%, 75.00%). SUVmax was significantly higher in malignant lesions [range 4.16-22.00, mean±standard deviation (x±s) 8.06±4.30] than in benign ones (range 1.18-6.25, x±s 2.82±1.02).

Conclusion: At present, whole-body (18)F-FDG PET/CT is an advanced diagnostic imaging technique in detecting loco-regional recurrence and metastasis in postoperative patients with colorectal carcinoma for its higher sensitivity and specificity.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Bone Neoplasms / diagnosis
  • Bone Neoplasms / secondary
  • Bone Neoplasms / surgery
  • Colorectal Neoplasms / diagnosis*
  • Colorectal Neoplasms / surgery
  • Female
  • Fluorodeoxyglucose F18*
  • Follow-Up Studies
  • Humans
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / secondary
  • Liver Neoplasms / surgery
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / secondary
  • Lung Neoplasms / surgery
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Monitoring, Physiologic
  • Neoplasm Recurrence, Local / diagnosis*
  • Neoplasm Recurrence, Local / surgery
  • Peritoneal Neoplasms / diagnosis
  • Peritoneal Neoplasms / secondary
  • Peritoneal Neoplasms / surgery
  • Positron-Emission Tomography*
  • Postoperative Care
  • Prognosis
  • Radiopharmaceuticals
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed*
  • Young Adult

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18