New pregnane saponins from Ecdysanthera rosea and their cytotoxicity

Fitoterapia. 2011 Jun;82(4):632-6. doi: 10.1016/j.fitote.2011.01.022. Epub 2011 Feb 4.

Abstract

Two new pregnane saponins elucidated as ecdysantheroside A (1) and ecdysantheroside B (2) and six known compounds (3-8) based on spectral data (MS, IR, 1D and 2D NMR) were isolated from the stem bark of Ecdysanthera rosea. The cytotoxicity against six cell lines of these compounds was tested by MTT assay. The results revealed that compounds 5 and 7 showed cytotoxicity against all the cell lines. Compound 2 showed cytotoxicity against cells A549, MDA435, HepG2, and HUVEC, while compound 4 showed cytotoxicity against cells A549, CEM, and HUVEC. Compound 6 had cytotoxicity against the others except cell HepG2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Apocynaceae / chemistry*
  • Drug Screening Assays, Antitumor
  • Hep G2 Cells
  • Humans
  • Molecular Structure
  • Pregnanes / isolation & purification*
  • Saponins / isolation & purification*

Substances

  • Antineoplastic Agents, Phytogenic
  • Pregnanes
  • Saponins
  • ecdysantheroside A
  • ecdysantheroside B